No Sex Differences in Inflammatory Response and Vascular Function During Low Estrogen Phase
نویسندگان
چکیده
Premenopausal women experience a lower incidence of cardiovascular disease as compared to age-matched men, partially due the cardioprotective effects estrogen. Acute inflammation increases pro-inflammatory cytokine production and reduces nitric oxide bioavailability, resulting in impaired vascular function. Estrogen has both anti-inflammatory pro-vasodilatory properties. During high estrogen mid-luteal phase menstrual cycle, sex differences function inflammatory responses induced have been observed premenopausal with men. However, limited knowledge exists regarding independent acute inflammation. Thus, our objective was evaluate inflammation- reduced influence concentration. Due dampening estrogen-related when concentrations are low, we hypothesized that would greater response men exhibit similar In double-blind crossover sham-controlled study 15 (21 ± 3y) 2y), assessed interleukin-6 concentration ([IL-6]) via brachial artery flow-mediated dilation (FMD) at baseline (BL), 24 hours (24H), 48 (48H) after influenza vaccine administration. Women were studied circulating levels typically low (early follicular or placebo pill oral contraceptive pills) between sexes. Following inflammation, sexes exhibited an increase [IL-6] 24H (BL v 24H: p=0.0049; p=0.0015) returned near by 48H 48H: p=0.43; p=0.29; (pg/mL): BL: 0.56 0.5, 1.14 0.7, 0.59 0.4; 0.38 0.2, 1.05 0.2). There no FMD any time point (FMD: p=0.062, p=0.30, interaction p=0.25; (%): 8.33 4.8, 6.40 4.4, 9.05 5.5; men: 5.25 2.9, 6.14 2.1, 6.71 1.1; [IL-6]: p=0.38, p=0.57, p=0.99). Notably, significantly resting diameter D; p<0.0001 all points) than D (mm): 3.22 0.4, 3.18 3.19 4.07 0.6, 4.24 48H, 4.22 0.4). difference diameter, allometrically scaled normalize variability there (sex p=0.11, p=0.20, p= 0.072; Scaled 6.39 3.7, 4.32 3.8, 6.92 3.7; 7.03 3.9, 8.71 4.2, 8.69 4.3). When show suggesting primary role previously
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: ['0892-6638', '1530-6860']
DOI: https://doi.org/10.1096/fasebj.2021.35.s1.02636